Promega Corporation

Detection of JNK, p38 and MAPK Enzyme Activation Using Anti-Dual-Phosphopeptide...

Detection of JNK, p38 and MAPK Enzyme Activation Using Anti-Dual-Phosphopeptide Antibodies: Coordinated Signaling of the Extracellular Signal-Regulated Protein Kinase (ERK) Superfamily


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The Extracellular Signal-Regulated Protein Kinase (ERK) superfamily is the focus of intensive study due to its widespread involvement in signaling pathways in both normal and disease states. Promega's Anti-ACTIVE™ MAPK, Anti-ACTIVE™ JNK and the soon to be released Anti-ACTIVE™ p38 pAbs provide researchers with a unique and rigorously tested panel of reagents to sort out the coordinated regulation of the ERK superfamily members. These antibodies can be used for a variety of non-radioactive applications, including Western blotting and immunocytochemistry, allowing a more accurate assessment of enzyme activation in response to a variety of extracellular stimuli.

Promega Notes 63, 2.

Bruce W. Jarvis1,  and Erik M. Schaefer1 and David T. Miller2

1Promega Corporation; 2Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO
Publication Date: 1997

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