Protein Kinase C Product Information

Literature # 9PIV526

Protein Kinase C (PKC) plays a crucial role in the initial events of signal transduction. Normal activation of PKC relies on the stimulation of phospholipid hydrolysis that follows a growth factor:receptor interaction. For example, phospholipase C mediates the hydrolysis of membrane inositol phospholipids to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate, which in turn triggers the release of calcium from intracellular stores. These products activate PKC by mediating its translocation from the cytosol to the membrane. Activated PKC subsequently phosphorylates serine and threonine residues on a variety of intracellular proteins. Many of the PKC target substrates are components of signal transduction pathways and include proteins that regulate ion channels, calcium- and calmodulin-binding proteins, growth factor receptors, structural and regulatory proteins of the cytoskeleton, components of the transcriptional machinery, efflux pumps and many other proteins.